A modular stand alone detector, offering an unrivalled level of sensitivity for fluorescence measurement
ZETALIF offers the opportunity to benefit from the most sensitive fluorescence detector now available. Using laser technology, Zeptomole limits of detection are now possible for some compounds. Picometrics offers the ZETALIF detectors with a broader range of lasers than any other vendor, giving the analysts a much larger choice of excitation wavelengths.

Sensitivity
Using a laser beam to excite the fluorescent molecules, combined with a number of advances in optical design, have made this detector's performance substantially unsurpassed. This tremendous improvement is due, in part, to the use of the unique patented collinear optical arrangement. For example, as little as 10-12 M Rhodamine 123 can be detected easily with a signal-to-noise ratio above 10 ( 75µm ID capillary flowcell, 488 nm Argon-Ion laser at 10 mW).
Versatility
The modular design of this new detector provides maximum versatility and ease of use. The ZETALIF detector can be used with virtually all separation techniques, including Capillary Electrophoresis, C.E.C., HPLC, Capillary LC, micro HPLC. The construction makes the instrument especially well-suited for on-column detection on a capillary, but allows a standard HPLC analytical flow cell to connect to the outlet end of the separation column. The most suitable wavelength can easily be selected by changing the laser, and inserting the appropriate filter set in the main unit.
Typical fields of interest
Neurochemistry, pharmacology, biochemistry, molecular biology, immunology, trace analysis of drugs in biological samples, environmental analysis, toxicology, oncology, cosmetology, food, forensic.
Applications The ZETALIF detect all fluorescent molecules, which are either natively fluorescent or made fluorescent after derivatization.
Native fluorescence
Pyrene, Aflatoxines Riboflavine Doxo/Daunorubicin Rhodamine	325 nm 442 nm 488 nm 488 nm
Fluorescent probes
Dansyl chloride OPA NDA CBQCA FITC DTAF NBD	325 nm 325nm 442 nm 442 nm 488 nm 488 nm 488 nm
	Sample : (1) Doxorubicin(2) Daunorubicin Injection volume : 5 µl Column : C18 Mobile phase : water/acetonitrile (70/30) pH = 4 Flow rate : 1 ml/min Laser : Ar Ion, 488 nm, 10 mW Concentrations : Doxorubicin is 2.10 -11 M, Daunorubicin is 10 -11 M